Interazioni tra farmaci
Amyl nitrite + Tadalafil
Gravità: Controindicata
Amyl nitrite and Tadalafil: contraindicated interaction.
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Sintesi
Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
Cosa significa questa interazione in parole semplici
Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Nitrite-derived nitric oxide raises cGMP and PDE5 inhibition prevents its degradation, causing excessive additive vasodilation.
Cosa fare
Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tadalafil
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide mononitrate + Tadalafil Controindicata
- Nitroglycerin po + Tadalafil Controindicata
- Nitroglycerin rectal + Tadalafil Controindicata
- Nitroglycerin sublingual + Tadalafil Controindicata
- Nitroglycerin transdermal + Tadalafil Controindicata
Domande frequenti
Can I take Amyl nitrite with Tadalafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amyl nitrite is a rapid, potent vasodilator, and tadalafil greatly enhances its hypotensive effect. Profound hypotension, collapse and cardiac ischemia can result, including with recreational inhaled nitrites.
How serious is the interaction between Amyl nitrite and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 48 hours after the last tadalafil dose before any nitrate. Advise patients to avoid recreational nitrites entirely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Isosorbide dinitrate, Isosorbide mononitrate, Nitroglycerin po. The full list is on the Tadalafil page.
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