Interazioni tra farmaci
Phenelzine + Phenylephrine
Gravità: Controindicata
Phenelzine and Phenylephrine: contraindicated interaction.
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Sintesi
Phenelzine is an irreversible MAO inhibitor, which can greatly amplify the pressor response to sympathomimetics. A hypertensive crisis may occur.
Cosa significa questa interazione in parole semplici
Phenelzine and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Perché avviene
Inhibition of MAO increases availability of norepinephrine and enhances the pressor response to phenylephrine.
Cosa fare
Avoid systemic phenylephrine in patients taking MAO inhibitors, including for two weeks after stopping. Use a non-sympathomimetic decongestant alternative.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Phenylephrine
- Isocarboxazid + Phenylephrine Controindicata
- Phenylephrine + Tranylcypromine Controindicata
- Bromocriptine + Phenylephrine Maggiore
- Cocaine + Phenylephrine Maggiore
- Dihydroergotamine intranasal + Phenylephrine Maggiore
- Dihydroergotamine + Phenylephrine Maggiore
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Phenelzine with Phenylephrine?
MediHelp rates the interaction as contraindicated. Phenelzine and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine is an irreversible MAO inhibitor, which can greatly amplify the pressor response to sympathomimetics. A hypertensive crisis may occur.
How serious is the interaction between Phenelzine and Phenylephrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic phenylephrine in patients taking MAO inhibitors, including for two weeks after stopping. Use a non-sympathomimetic decongestant alternative.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Tranylcypromine, Bromocriptine. The full list is on the Phenylephrine page.
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