Interazioni tra farmaci
Phenylephrine + Tranylcypromine
Gravità: Controindicata
Phenylephrine and Tranylcypromine: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Tranylcypromine is an irreversible MAO inhibitor, and sympathomimetics can precipitate a hypertensive crisis. This may cause severe headache, stroke or death.
Cosa significa questa interazione in parole semplici
Phenylephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenylephrine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Perché avviene
Inhibition of MAO enhances norepinephrine stores and the pressor response to phenylephrine.
Cosa fare
Do not combine; avoid systemic phenylephrine during and for two weeks after tranylcypromine. Choose non-sympathomimetic alternatives.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
- Tranylcypromine - FDA drug label (DailyMed) — openFDA / DailyMed
Altre interazioni di Phenylephrine
- Isocarboxazid + Phenylephrine Controindicata
- Phenelzine + Phenylephrine Controindicata
- Bromocriptine + Phenylephrine Maggiore
- Cocaine + Phenylephrine Maggiore
- Dihydroergotamine intranasal + Phenylephrine Maggiore
- Dihydroergotamine + Phenylephrine Maggiore
Altre interazioni di Tranylcypromine
- 5-HTP + Tranylcypromine Controindicata
- Amitriptyline + Tranylcypromine Controindicata
- Amoxapine + Tranylcypromine Controindicata
- Atomoxetine + Tranylcypromine Controindicata
- Benzphetamine + Tranylcypromine Controindicata
- Brimonidine + Tranylcypromine Controindicata
Domande frequenti
Can I take Phenylephrine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Phenylephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine is an irreversible MAO inhibitor, and sympathomimetics can precipitate a hypertensive crisis. This may cause severe headache, stroke or death.
How serious is the interaction between Phenylephrine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid systemic phenylephrine during and for two weeks after tranylcypromine. Choose non-sympathomimetic alternatives.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Bromocriptine. The full list is on the Phenylephrine page.
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