Interazioni tra farmaci
Isocarboxazid + Phenylephrine
Gravità: Controindicata
Isocarboxazid and Phenylephrine: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
Cosa significa questa interazione in parole semplici
Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Perché avviene
MAO inhibition potentiating sympathomimetic/pressor activity
Cosa fare
Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Isocarboxazid e Phenylephrine, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Phenylephrine
- Phenelzine + Phenylephrine Controindicata
- Phenylephrine + Tranylcypromine Controindicata
- Bromocriptine + Phenylephrine Maggiore
- Cocaine + Phenylephrine Maggiore
- Dihydroergotamine intranasal + Phenylephrine Maggiore
- Dihydroergotamine + Phenylephrine Maggiore
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Domande frequenti
Can I take Isocarboxazid with Phenylephrine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
How serious is the interaction between Isocarboxazid and Phenylephrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Phenelzine, Tranylcypromine, Bromocriptine. The full list is on the Phenylephrine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
