Interazioni tra farmaci
Pimozide + Trimipramine
Gravità: Controindicata
Pimozide and Trimipramine: contraindicated interaction.
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Sintesi
Both drugs prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against drugs with QT-prolonging effects.
Cosa significa questa interazione in parole semplici
Pimozide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Perché avviene
Additive cardiac repolarization delay through hERG potassium channel blockade; possible CYP2D6 interplay.
Cosa fare
Avoid the combination and select an antidepressant with less QT effect. Check ECG and electrolytes if no alternative exists.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Trimipramine
- Disopyramide + Trimipramine Controindicata
- Dofetilide + Trimipramine Controindicata
- Ibutilide + Trimipramine Controindicata
- Isocarboxazid + Trimipramine Controindicata
- Pentamidine + Trimipramine Controindicata
- Phenelzine + Trimipramine Controindicata
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Pimozide with Trimipramine?
MediHelp rates the interaction as contraindicated. Pimozide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling cautions against drugs with QT-prolonging effects.
How serious is the interaction between Pimozide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antidepressant with less QT effect. Check ECG and electrolytes if no alternative exists.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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