Interazioni tra farmaci
Isocarboxazid + Trimipramine
Gravità: Controindicata
Isocarboxazid and Trimipramine: contraindicated interaction.
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Sintesi
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and trimipramine is a tricyclic antidepressant with serotonergic activity. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
Cosa significa questa interazione in parole semplici
Isocarboxazid and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Perché avviene
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
Cosa fare
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting trimipramine, and at least 14 days after stopping trimipramine before starting isocarboxazid.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Trimipramine
- Disopyramide + Trimipramine Controindicata
- Dofetilide + Trimipramine Controindicata
- Ibutilide + Trimipramine Controindicata
- Pentamidine + Trimipramine Controindicata
- Phenelzine + Trimipramine Controindicata
- Pimozide + Trimipramine Controindicata
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Domande frequenti
Can I take Isocarboxazid with Trimipramine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and trimipramine is a tricyclic antidepressant with serotonergic activity. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Isocarboxazid and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting trimipramine, and at least 14 days after stopping trimipramine before starting isocarboxazid.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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