Interazioni tra farmaci
Disopyramide + Trimipramine
Gravità: Controindicata
Disopyramide and Trimipramine: contraindicated interaction.
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Sintesi
Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.
Cosa significa questa interazione in parole semplici
Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Trimipramine belongs to Central Nervous System.
Perché avviene
Additive QT prolongation and sodium channel blockade, plus additive anticholinergic effects.
Cosa fare
Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Trimipramine
- Dofetilide + Trimipramine Controindicata
- Ibutilide + Trimipramine Controindicata
- Isocarboxazid + Trimipramine Controindicata
- Pentamidine + Trimipramine Controindicata
- Phenelzine + Trimipramine Controindicata
- Pimozide + Trimipramine Controindicata
Altre interazioni di Disopyramide
- Amisulpride + Disopyramide Controindicata
- Desipramine + Disopyramide Controindicata
- Disopyramide + Dronedarone Controindicata
- Disopyramide + Itraconazole Controindicata
- Disopyramide + Ketoconazole Controindicata
- Disopyramide + Maprotiline Controindicata
Domande frequenti
Can I take Disopyramide with Trimipramine?
MediHelp rates the interaction as contraindicated. Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.
How serious is the interaction between Disopyramide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Dofetilide, Ibutilide, Isocarboxazid. The full list is on the Trimipramine page.
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