Interazioni tra farmaci
Procarbazine + Venlafaxine
Gravità: Controindicata
Procarbazine and Venlafaxine: contraindicated interaction.
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Sintesi
Procarbazine has MAO-inhibiting properties, so combining it with venlafaxine may cause serotonin syndrome or hypertensive reactions. Evidence is mostly extrapolated from MAOI class effects.
Cosa significa questa interazione in parole semplici
Procarbazine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Perché avviene
Weak MAO inhibition by procarbazine adds to venlafaxine's serotonin and noradrenaline reuptake inhibition.
Cosa fare
Avoid the combination and allow at least 14 days after stopping procarbazine before starting venlafaxine. Use a non-serotonergic alternative if an antidepressant is needed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Venlafaxine
- Isocarboxazid + Venlafaxine Controindicata
- Methylene blue + Venlafaxine Controindicata
- Phenelzine + Venlafaxine Controindicata
- Rasagiline + Venlafaxine Controindicata
- Safinamide + Venlafaxine Controindicata
- Selegiline transdermal + Venlafaxine Controindicata
Altre interazioni di Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amoxapine + Procarbazine Controindicata
- Atomoxetine + Procarbazine Controindicata
- Bcg vaccine live + Procarbazine Controindicata
- Brimonidine + Procarbazine Controindicata
Domande frequenti
Can I take Procarbazine with Venlafaxine?
MediHelp rates the interaction as contraindicated. Procarbazine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, so combining it with venlafaxine may cause serotonin syndrome or hypertensive reactions. Evidence is mostly extrapolated from MAOI class effects.
How serious is the interaction between Procarbazine and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow at least 14 days after stopping procarbazine before starting venlafaxine. Use a non-serotonergic alternative if an antidepressant is needed.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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