Interazioni tra farmaci
Safinamide + Venlafaxine
Gravità: Controindicata
Safinamide and Venlafaxine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Safinamide, an MAO-B inhibitor, combined with venlafaxine may cause serotonin syndrome or hypertensive reactions. Safinamide labeling contraindicates use with SNRIs.
Cosa significa questa interazione in parole semplici
Safinamide and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Perché avviene
MAO-B inhibition together with serotonin-noradrenaline reuptake inhibition increases monoamine activity.
Cosa fare
Do not combine. Observe at least 14 days after stopping safinamide before starting venlafaxine, and an adequate washout of venlafaxine before starting safinamide.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Venlafaxine
- Isocarboxazid + Venlafaxine Controindicata
- Methylene blue + Venlafaxine Controindicata
- Phenelzine + Venlafaxine Controindicata
- Procarbazine + Venlafaxine Controindicata
- Rasagiline + Venlafaxine Controindicata
- Selegiline transdermal + Venlafaxine Controindicata
Altre interazioni di Safinamide
- Amitriptyline + Safinamide Controindicata
- Amoxapine + Safinamide Controindicata
- Amphetamine polistirex + Safinamide Controindicata
- Clomipramine + Safinamide Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Desipramine + Safinamide Controindicata
Domande frequenti
Can I take Safinamide with Venlafaxine?
MediHelp rates the interaction as contraindicated. Safinamide and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide, an MAO-B inhibitor, combined with venlafaxine may cause serotonin syndrome or hypertensive reactions. Safinamide labeling contraindicates use with SNRIs.
How serious is the interaction between Safinamide and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Observe at least 14 days after stopping safinamide before starting venlafaxine, and an adequate washout of venlafaxine before starting safinamide.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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