Interazioni tra farmaci
Rifampicin + Thalidomide
Gravità: Maggiore
Rifampicin and Thalidomide: major interaction.
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Sintesi
Rifampicin is a strong enzyme inducer that substantially lowers hormonal contraceptive levels, risking contraceptive failure. With thalidomide, a pregnancy would carry a risk of severe birth defects.
Cosa significa questa interazione in parole semplici
Rifampicin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Thalidomide belongs to Miscellaneous.
Perché avviene
Induction of CYP3A4 and other enzymes by rifampicin increases contraceptive hormone metabolism.
Cosa fare
Do not depend on hormonal contraceptives; use a non-hormonal highly effective method such as a copper IUD plus a barrier method during and for several weeks after rifampicin.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Thalidomide
- Bortezomib + Thalidomide Maggiore
- Carbamazepine + Thalidomide Maggiore
- Griseofulvin + Thalidomide Maggiore
- Modafinil + Thalidomide Maggiore
- Nivolumab + Thalidomide Maggiore
- Phenytoin + Thalidomide Maggiore
Altre interazioni di Rifampicin
- Cabotegravir + Rifampicin Controindicata
- Delamanid + Rifampicin Controindicata
- Doravirine + Rifampicin Controindicata
- Ensitrelvir + Rifampicin Controindicata
- Fostemsavir + Rifampicin Controindicata
- Isavuconazole + Rifampicin Controindicata
Domande frequenti
Can I take Rifampicin with Thalidomide?
MediHelp rates the interaction as major. Rifampicin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin is a strong enzyme inducer that substantially lowers hormonal contraceptive levels, risking contraceptive failure. With thalidomide, a pregnancy would carry a risk of severe birth defects.
How serious is the interaction between Rifampicin and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not depend on hormonal contraceptives; use a non-hormonal highly effective method such as a copper IUD plus a barrier method during and for several weeks after rifampicin.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
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