Interazioni tra farmaci
Roxadustat + Simvastatin
Gravità: Moderata
Roxadustat and Simvastatin: moderate interaction.
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Sintesi
Roxadustat raises simvastatin exposure, increasing the chance of statin-related muscle toxicity. Simvastatin is already prone to myopathy at higher exposures.
Cosa significa questa interazione in parole semplici
Roxadustat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roxadustat belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Perché avviene
Roxadustat inhibits OATP1B1 and BCRP, reducing hepatic uptake and efflux of statins.
Cosa fare
Monitor for muscle pain, weakness and CK elevation. Consider reducing the simvastatin dose.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Roxadustat
- Gemfibrozil + Roxadustat Maggiore
- Probenecid + Roxadustat Maggiore
- Atorvastatin + Roxadustat Moderata
- Calcium acetate + Roxadustat Moderata
- Calcium + Roxadustat Moderata
- Iron + Roxadustat Moderata
Altre interazioni di Simvastatin
- Atazanavir + Simvastatin Controindicata
- Clarithromycin + Simvastatin Controindicata
- Cobicistat + Simvastatin Controindicata
- Cyclosporine + Simvastatin Controindicata
- Cyclosporin + Simvastatin Controindicata
- Danazol + Simvastatin Controindicata
Domande frequenti
Can I take Roxadustat with Simvastatin?
MediHelp rates the interaction as moderate. Roxadustat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Roxadustat raises simvastatin exposure, increasing the chance of statin-related muscle toxicity. Simvastatin is already prone to myopathy at higher exposures.
How serious is the interaction between Roxadustat and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation. Consider reducing the simvastatin dose.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
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