Riferimento farmaci
Roxadustat
Roxadustat is a medicine in the class miscellaneous. It is used for anemia.
- Classe del farmaco: Miscellaneous
- Indicato per: anemia
Ultimo aggiornamento Fonti: EMA SmPC
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In breve
- Classe del farmaco
- Miscellaneous
- Codice ATC
- B03XA05
- Dosaggi comuni
- 100 mg
- Interazioni note
- 10 (Maggiore: 2 · Moderata: 8)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Hypoxia-inducible factor prolyl hydroxylase inhibitor. Reversible HIF-PH inhibition raises endogenous erythropoietin, regulates iron transporter proteins and reduces hepcidin, improving iron availability and increasing Hb production and red cell mass.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Symptomatic anaemia of CKD, ESA-naive: 70 mg orally three times per week (not on consecutive days) if under 100 kg; 100 mg three times per week if 100 kg or over.
Gravidanza e allattamento
- Gravidanza
- Unsafe No human data; animal reproductive toxicity. Contraindicated in the third trimester; not recommended in the first and second trimesters.
- Allattamento
- Unsafe Unknown whether excreted in human milk; excreted in animal milk. Contraindicated during breast-feeding.
Effetti indesiderati segnalati
- Hypertension
- Vascular access thrombosis
- Diarrhoea
- Peripheral oedema
- Hyperkalaemia
- Nausea
Controindicazioni
- Hypersensitivity to the active substance, peanut, soya or any excipient.
- Third trimester of pregnancy.
- Breast-feeding.
Chi deve prestare attenzione
- Cardiovascular and mortality risk is estimated as comparable to ESA therapy; in non-dialysis patients the risk versus placebo could not be estimated. Converting stable ESA-treated dialysis patients only with a valid clinical reason.
- Thrombotic vascular events (DVT, PE, cerebral infarction, vascular access thrombosis) occur; weigh risk especially with obesity or prior TVE; avoid Hb above 12 g/dL or a rise above 2 g/dL over 4 weeks.
- Seizures: use with caution in patients with a history of seizures, epilepsy or CNS infections.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (10)
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Iron + Roxadustat Moderate
- Magnesium + Roxadustat Moderate
- Rosuvastatin + Roxadustat Moderate
- Roxadustat + Sevelamer Moderate
- Roxadustat + Simvastatin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
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- Pharmacokinetics
- Patient counselling points
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Altri farmaci della stessa classe
Domande frequenti
What is Roxadustat used for?
Roxadustat is a medicine in the class miscellaneous. It is used for Anemia.
What side effects have been reported with Roxadustat?
Hypertension, Vascular access thrombosis, Diarrhoea, Peripheral oedema, Hyperkalaemia, Nausea.
Can Roxadustat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data; animal reproductive toxicity. Contraindicated in the third trimester; not recommended in the first and second trimesters. Breastfeeding: Unsafe. Unknown whether excreted in human milk; excreted in animal milk. Contraindicated during breast-feeding.
What does Roxadustat interact with?
MediHelp lists 10 known interactions for Roxadustat. Major: 2 · Moderate: 8. The most serious include Gemfibrozil, Probenecid, Atorvastatin.
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