Interazioni tra farmaci
Sofosbuvir-velpatasvir-voxilaprevir + St john's wort
Gravità: Controindicata
Sofosbuvir-velpatasvir-voxilaprevir and St john's wort: contraindicated interaction.
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Sintesi
St John's wort induces P-glycoprotein and CYP enzymes, which can substantially reduce exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks subtherapeutic antiviral levels and treatment failure.
Cosa significa questa interazione in parole semplici
Sofosbuvir-velpatasvir-voxilaprevir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Induction of P-glycoprotein and CYP3A4/CYP2B6/CYP2C8 by hyperforin reduces absorption and increases metabolism of the HCV drugs.
Cosa fare
Avoid the combination; labeling advises against use with St John's wort. Stop the herbal product before starting HCV therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
Domande frequenti
Can I take Sofosbuvir-velpatasvir-voxilaprevir with St john's wort?
MediHelp rates the interaction as contraindicated. Sofosbuvir-velpatasvir-voxilaprevir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort induces P-glycoprotein and CYP enzymes, which can substantially reduce exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks subtherapeutic antiviral levels and treatment failure.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against use with St John's wort. Stop the herbal product before starting HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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