Interazioni tra farmaci
Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir
Gravità: Controindicata
Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Phenytoin induces CYP3A4, CYP2B6 and P-gp and is expected to substantially lower exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks virologic failure. Labeling recommends against use together.
Cosa significa questa interazione in parole semplici
Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenytoin belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Perché avviene
Induction of CYP enzymes and P-glycoprotein by phenytoin reduces absorption and increases clearance of the antiviral components.
Cosa fare
Do not coadminister; change to a non-inducing antiepileptic before starting HCV therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Controindicata
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort Controindicata
Altre interazioni di Phenytoin
- Artemether / lumefantrine + Phenytoin Controindicata
- Bictegravir + Phenytoin Controindicata
- Cabotegravir + Phenytoin Controindicata
- Doravirine + Phenytoin Controindicata
- Elbasvir / grazoprevir + Phenytoin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Controindicata
Domande frequenti
Can I take Phenytoin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin induces CYP3A4, CYP2B6 and P-gp and is expected to substantially lower exposure to sofosbuvir, velpatasvir and voxilaprevir. This risks virologic failure. Labeling recommends against use together.
How serious is the interaction between Phenytoin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; change to a non-inducing antiepileptic before starting HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Primidone. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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