医薬品リファレンス
Carbimazole
Carbimazole is a medicine in the class endocrine. It is used for hyperthyroidism.
- 薬効分類: Endocrine
- 効能・効果: hyperthyroidism
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Endocrine
- 一般的な剤形
- 錠剤
- 一般的な規格
- 5 mg, 20 mg
- 既知の相互作用
- 2 (中等度: 2)
- 商品名
- 10
- 国・市場
- 4
何に使われるか
作用のしくみ
Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis. Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine.
成人の通常用量（添付文書の要約）
Initial dose is in the range 20 mg to 60 mg, taken as two to three divided doses.
妊娠と授乳
- 妊娠
- Unsafe Suspected to cause birth defects with 1st-trimester use (scalp, gut and abdominal wall defects). Use effective contraception; in early pregnancy propylthiouracil is usually preferred. If needed later, use the lowest dose and monitor mother, fetus and newborn thyroid.
- 授乳
- Safe Converted to methimazole, which passes into milk. UK label: do not breastfeed if treatment continues. LactMed and thyroid guidelines: moderate doses are acceptable and do not affect infant thyroid function; monitor infant growth.
報告されている副作用
- Headache
- Nausea
- Angioedema
- Bone marrow depression
- Acute pancreatitis
注意が必要な方
- Patients unable to comply with the instructions for use or who cannot be monitored regularly should not be treated with carbimazole.
- Carbimazole tablets should be used with caution in patients with mild-moderate hepatic insufficiency.
- Precaution should be taken in patients with intrathoracic goitre, which may worsen during initial treatment with carbimazole
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (2)
- Carbimazole + Rosuvastatin Moderate
- Carbimazole + Tiratricol Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Carbimazoleの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Carbimazole used for?
Carbimazole is a medicine in the class endocrine. It is used for Hyperthyroidism.
What side effects have been reported with Carbimazole?
Headache, Nausea, Angioedema, Bone marrow depression, Acute pancreatitis.
Can Carbimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Suspected to cause birth defects with 1st-trimester use (scalp, gut and abdominal wall defects). Use effective contraception; in early pregnancy propylthiouracil is usually preferred. If needed later, use the lowest dose and monitor mother, fetus and newborn thyroid. Breastfeeding: Safe. Converted to methimazole, which passes into milk. UK label: do not breastfeed if treatment continues. LactMed and thyroid guidelines: moderate doses are acceptable and do not affect infant thyroid function; monitor infant growth.
What does Carbimazole interact with?
MediHelp lists 2 known interactions for Carbimazole. Moderate: 2. The most serious include Rosuvastatin, Tiratricol.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
