医薬品リファレンス
Methimazole
Methimazole is a medicine in the class endocrine. It is used for graves disease.
- 薬効分類: Endocrine
- 効能・効果: graves disease
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Endocrine
- 既知の相互作用
- 15 (重大: 4 · 中等度: 8 · 軽度: 3)
何に使われるか
作用のしくみ
Inhibits synthesis of thyroid hormone by blocking oxidation of iodine in thyroid gland; blocks synthesis of thyroxine (T4) and triiodothyronine (T3)
成人の通常用量（添付文書の要約）
Hyperthyroidism: Mild: 15 mg/day PO divided q8hr initially, Moderate: 30-40 mg/day PO divided q8hr initially
妊娠と授乳
- 妊娠
- Unsafe Crosses the placenta. 1st-trimester use is linked to rare birth defects (scalp skin defects, oesophageal or choanal atresia, abdominal wall defects). Propylthiouracil is usually preferred in the 1st trimester, then methimazole. Use the lowest dose; monitor maternal and fetal/newborn thyroid.
- 授乳
- Safe Passes into milk, but a long-term study of 139 mothers found no infant toxicity, and doses up to 20 mg daily do not affect infant thyroid function. LactMed: some experts consider it the antithyroid drug of choice; take it right after a feed. US label: monitor thyroid function.
報告されている副作用
- Rash
- Hepatotoxicity
- Pruritus
- Alopecia
- Agranulocytosis
- Aplastic anemia
注意が必要な方
- Antineutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis reported; discontinue use in presence of vasculitis
- Concurrent administration of other agranulocytosis-causing drugs
- Significant bone marrow suppression may occur; use caution if administered with other agents known to cause myelosupression; discontinue if significan agranulocytosis
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (15)
- Carbamazepine + Methimazole Major
- Clozapine + Methimazole Major
- Methimazole + Propylthiouracil Major
- Methimazole + Sodium iodide i-131 Major
- Iodinated glycerol + Methimazole Moderate
- Iodine + Methimazole Moderate
- Lycopus + Methimazole Moderate
- Methimazole + Phenindione Moderate
- Methimazole + Potassium iodide Moderate
- Methimazole + Ropeginterferon alfa 2b Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Methimazoleの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Methimazole used for?
Methimazole is a medicine in the class endocrine. It is used for Graves disease, Hyperthyroidism, Melasma.
What side effects have been reported with Methimazole?
Rash, Hepatotoxicity, Pruritus, Alopecia, Agranulocytosis, Aplastic anemia.
Can Methimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Crosses the placenta. 1st-trimester use is linked to rare birth defects (scalp skin defects, oesophageal or choanal atresia, abdominal wall defects). Propylthiouracil is usually preferred in the 1st trimester, then methimazole. Use the lowest dose; monitor maternal and fetal/newborn thyroid. Breastfeeding: Safe. Passes into milk, but a long-term study of 139 mothers found no infant toxicity, and doses up to 20 mg daily do not affect infant thyroid function. LactMed: some experts consider it the antithyroid drug of choice; take it right after a feed. US label: monitor thyroid function.
What does Methimazole interact with?
MediHelp lists 15 known interactions for Methimazole. Major: 4 · Moderate: 8 · Minor: 3. The most serious include Carbamazepine, Clozapine, Propylthiouracil.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
