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Tiratricol

Tiratricol is a medicine in the class endocrine.

  • 薬効分類: Endocrine

最終更新日 出典: EMA SmPC

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Endocrine
ATCコード
H03AA04
既知の相互作用
13 (重大: 1 · 中等度: 12)
商品名
1
国・市場
1

作用のしくみ

Tiratricol is a naturally circulating metabolite of T3 that binds with high affinity to thyroid hormone receptors TRα and TRβ and has T3-like effects. It can enter MCT8-dependent cells without a functioning MCT8 transporter, so it can replace T3 in MCT8-dependent tissues.

成人の通常用量（添付文書の要約）

Peripheral thyrotoxicosis in MCT8 deficiency, body weight 10 kg or above (adults, adolescents, children, infants): start 350 micrograms daily orally or via feeding tube in 1 to 3 doses; increase by 350 micrograms every two weeks to maintenance; target serum T3 below midpoint of normal range for age.

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unsafe Contraindicated in pregnancy (EU): it crosses the placenta and animal studies showed reproductive toxicity. Women who could become pregnant must use effective contraception. Used for MCT8 deficiency, which almost only affects males.
授乳
Unknown Not known if it passes into milk; no LactMed record. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. e-lactancia: limited compatibility (a thyroid hormone analogue); prefer a safer option or stop breastfeeding.

報告されている副作用

  • Hyperhidrosis
  • Diarrhoea
  • Irritability
  • Anxiety
  • Nightmares

禁忌

  • Hypersensitivity to the active substance or any excipient.
  • Hyperthyroidism for reasons other than MCT8 deficiency (e.g. Graves' disease).
  • Pregnancy.

注意が必要な方

  • Hypermetabolic signs and symptoms (hyperhidrosis, irritability, anxiety, insomnia, tachycardia, diarrhoea etc.) may occur at initiation or during titration; reduce dose if not resolved within 2 weeks.
  • Use caution during titration in patients with cardiac disease.
  • Tiratricol cross-reacts with T3 in immunoassays, giving unreliable results; LC/MS/MS is recommended.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (13)

All 13 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Tiratricolの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • IV preparation and dilution
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同じ分類のほかの薬剤

よくある質問

What is Tiratricol used for?

Tiratricol is a medicine in the class endocrine.

What side effects have been reported with Tiratricol?

Hyperhidrosis, Diarrhoea, Irritability, Anxiety, Nightmares.

Can Tiratricol be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Contraindicated in pregnancy (EU): it crosses the placenta and animal studies showed reproductive toxicity. Women who could become pregnant must use effective contraception. Used for MCT8 deficiency, which almost only affects males. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. e-lactancia: limited compatibility (a thyroid hormone analogue); prefer a safer option or stop breastfeeding.

What does Tiratricol interact with?

MediHelp lists 13 known interactions for Tiratricol. Major: 1 · Moderate: 12. The most serious include Levothyroxine, Calcium, Carbamazepine.

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