医薬品リファレンス
Cimetidine
Cimetidine is a medicine in the class gastrointestinal tract. It is used for duodenal ulcer.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: duodenal ulcer
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Gastrointestinal Tract
- 一般的な剤形
- 錠剤, 経口懸濁液, 注射剤
- 一般的な規格
- 200 mg, 400 mg, 200 mg/2 ml
- 既知の相互作用
- 405 (併用禁忌: 2 · 重大: 31 · 中等度: 179 · 軽度: 193)
- 商品名
- 21
- 国・市場
- 4
何に使われるか
作用のしくみ
H2-receptor antagonist; blocks H2-receptors of gastric parietal cells, leading to inhibition of gastric secretions, Relative Potency: 1.
成人の通常用量（添付文書の要約）
Benign Gastric Ulcer: 800 mg PO qHS OR 400 mg PO q12hr OR 300 mg PO q6hr
妊娠と授乳
- 妊娠
- Safe Large studies show no increase in birth defects. Acceptable for heartburn or ulcers when antacids are not enough; famotidine is often preferred because cimetidine has more drug interactions.
- 授乳
- Safe US label advises against breastfeeding. LactMed: passes into milk at levels above maternal blood, but infant doses are small and no harm has been reported, so it is acceptable; famotidine is often preferred.
報告されている副作用
- Headache
- Somnolence
- Dizziness
- Gynecomastia
禁忌
- Hypersensitivity to cimetidine or other H2 receptor antagonists
注意が必要な方
- Due to its severe interactions and side effects, its use is not recommended with the availability of other safer H2 Blockers.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (405)
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
- Cimetidine + Clozapine Major
- Cimetidine + Dasatinib Major
- Cimetidine + Dihydroergotamine Major
- Cimetidine + Dihydroergotamine intranasal Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cimetidineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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よくある質問
What is Cimetidine used for?
Cimetidine is a medicine in the class gastrointestinal tract. It is used for Duodenal ulcer, GERD, Peptic ulcer, Zollinger-ellison syndrome.
What side effects have been reported with Cimetidine?
Headache, Somnolence, Dizziness, Gynecomastia.
Can Cimetidine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Large studies show no increase in birth defects. Acceptable for heartburn or ulcers when antacids are not enough; famotidine is often preferred because cimetidine has more drug interactions. Breastfeeding: Safe. US label advises against breastfeeding. LactMed: passes into milk at levels above maternal blood, but infant doses are small and no harm has been reported, so it is acceptable; famotidine is often preferred.
What does Cimetidine interact with?
MediHelp lists 405 known interactions for Cimetidine. Contraindicated: 2 · Major: 31 · Moderate: 179 · Minor: 193. The most serious include Dofetilide, Fezolinetant, Alfentanil.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
