医薬品リファレンス
Dacomitinib
Dacomitinib is a medicine in the class oncology. It is used for non-small cell lung cancer.
- 薬効分類: Oncology
- 効能・効果: non-small cell lung cancer
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- ATCコード
- L01EB07
- 一般的な剤形
- 錠剤
- 一般的な規格
- 15 mg
- 既知の相互作用
- 53 (併用禁忌: 1 · 重大: 20 · 中等度: 24 · 軽度: 8)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Irreversible inhibitor of the kinase activity of the human EGFR family (EGFR/HER1, HER2, HER4) and of EGFR activating mutations (exon 19 deletion, exon 21 L858R substitution).
成人の通常用量（添付文書の要約）
First-line metastatic NSCLC with EGFR exon 19 deletion or exon 21 L858R mutation: 45 mg orally once daily, with or without food, until disease progression or unacceptable toxicity; take at the same time each day
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm based on animal studies and mechanism of action; no human data. Use effective contraception during treatment and for at least 17 days after the final dose.
- 授乳
- Unsafe No information on presence in human milk. Advise not to breastfeed during treatment and for at least 17 days after the last dose.
報告されている副作用
- Diarrhea
- Rash
- Paronychia
- Stomatitis
- Decreased appetite
- Dry skin
禁忌
- None.
注意が必要な方
- Severe and fatal ILD/pneumonitis occurred; monitor for pulmonary symptoms, withhold if suspected and permanently discontinue if confirmed.
- Severe and fatal diarrhea occurred; promptly initiate anti-diarrheal treatment and withhold for Grade 2 or greater.
- Rash and exfoliative skin reactions occurred; use moisturizers and limit sun exposure; treat with topical or oral antibiotics and topical steroids by grade.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (53)
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
- Dacomitinib + Dexlansoprazole Major
- Dacomitinib + Esomeprazole Major
- Dacomitinib + Flecainide Major
- Dacomitinib + Imipramine Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dacomitinibの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Dacomitinib used for?
Dacomitinib is a medicine in the class oncology. It is used for Non-small cell lung cancer.
What side effects have been reported with Dacomitinib?
Diarrhea, Rash, Paronychia, Stomatitis, Decreased appetite, Dry skin.
Can Dacomitinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm based on animal studies and mechanism of action; no human data. Use effective contraception during treatment and for at least 17 days after the final dose. Breastfeeding: Unsafe. No information on presence in human milk. Advise not to breastfeed during treatment and for at least 17 days after the last dose.
What does Dacomitinib interact with?
MediHelp lists 53 known interactions for Dacomitinib. Contraindicated: 1 · Major: 20 · Moderate: 24 · Minor: 8. The most serious include Thioridazine, Amitriptyline, Atomoxetine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
