相互作用
Dacomitinib + Thioridazine
重症度: 併用禁忌
Dacomitinib and Thioridazine: contraindicated interaction.
最終更新日
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概要
Dacomitinib strongly inhibits CYP2D6, which is the main route of thioridazine clearance. Higher thioridazine levels increase the risk of QT prolongation and torsades de pointes.
この相互作用をわかりやすく説明すると
Dacomitinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dacomitinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Dacomitinib inhibits CYP2D6, reducing thioridazine metabolism and raising its concentrations.
対処法
Avoid the combination; use an antipsychotic not dependent on CYP2D6 or an alternative EGFR inhibitor. If unavoidable, monitor ECG closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、DacomitinibとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Thioridazineのその他の相互作用
Dacomitinibのその他の相互作用
よくある質問
Can I take Dacomitinib with Thioridazine?
MediHelp rates the interaction as contraindicated. Dacomitinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dacomitinib strongly inhibits CYP2D6, which is the main route of thioridazine clearance. Higher thioridazine levels increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Dacomitinib and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antipsychotic not dependent on CYP2D6 or an alternative EGFR inhibitor. If unavoidable, monitor ECG closely.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
