相互作用
Amitriptyline + Dacomitinib
重症度: 重大
Amitriptyline and Dacomitinib: major interaction.
最終更新日
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概要
Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise amitriptyline concentrations. This may increase anticholinergic effects, sedation, QT prolongation and arrhythmia risk.
この相互作用をわかりやすく説明すると
Amitriptyline and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Dacomitinib belongs to Oncology.
なぜ起こるのか
Dacomitinib inhibits CYP2D6, reducing the metabolism of amitriptyline and its active metabolite.
対処法
Avoid if possible or reduce the amitriptyline dose and monitor for toxicity. Check an ECG and consider tricyclic levels in higher-risk patients.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとDacomitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Dacomitinibのその他の相互作用
よくある質問
Can I take Amitriptyline with Dacomitinib?
MediHelp rates the interaction as major. Amitriptyline and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise amitriptyline concentrations. This may increase anticholinergic effects, sedation, QT prolongation and arrhythmia risk.
How serious is the interaction between Amitriptyline and Dacomitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or reduce the amitriptyline dose and monitor for toxicity. Check an ECG and consider tricyclic levels in higher-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
