医薬品リファレンス
Ephedrine
Ephedrine is a medicine in the class cardiovascular. It is used for hypotension.
- 薬効分類: Cardiovascular
- 効能・効果: hypotension
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Cardiovascular
- 一般的な剤形
- 錠剤, 注射剤
- 一般的な規格
- 5 mg/ml, 12.5 mg, 25 mg
- 既知の相互作用
- 170 (併用禁忌: 6 · 重大: 6 · 中等度: 88 · 軽度: 70)
- 商品名
- 5
- 国・市場
- 2
何に使われるか
作用のしくみ
Sympathomimetic amine that directly agonizes alpha- and beta-adrenergic receptors and indirectly causes norepinephrine release from sympathetic neurons, raising arterial pressure, cardiac output and peripheral resistance.
成人の通常用量（添付文書の要約）
Clinically important hypotension in the setting of anesthesia: initial 5 mg to 10 mg IV bolus; additional boluses as needed; titrate to blood pressure goal; total not to exceed 50 mg
妊娠と授乳
- 妊娠
- Unknown Available human data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; neonatal metabolic acidosis reported with maternal exposure, so monitor newborn. Animal decreased fetal survival and weight occurred with maternal toxicity.
- 授乳
- Unknown Ephedrine is present in human milk in a single case report; effects on infant and milk production unknown. Weigh breastfeeding benefits against maternal need.
報告されている副作用
- Nausea
- Vomiting
- Tachycardia
- Palpitations
- Reactive hypertension
- Bradycardia
禁忌
- None
注意が必要な方
- Serious postpartum hypertension, some with stroke, reported with vasopressor plus oxytocic; monitor blood pressure carefully.
- Repeated administration can cause tachyphylaxis; have an alternative pressor ready.
- Prophylactic use to prevent hypotension is associated with increased incidence of hypertension compared with treatment of hypotension.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (170)
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
- Caffeine + Ephedrine Major
- Ephedrine + Ergotamine Major
- Ephedrine + Linezolid Major
- Ephedrine + Maprotiline Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ephedrineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- IV preparation and dilution
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よくある質問
What is Ephedrine used for?
Ephedrine is a medicine in the class cardiovascular. It is used for Hypotension.
What side effects have been reported with Ephedrine?
Nausea, Vomiting, Tachycardia, Palpitations, Reactive hypertension, Bradycardia.
Can Ephedrine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Available human data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; neonatal metabolic acidosis reported with maternal exposure, so monitor newborn. Animal decreased fetal survival and weight occurred with maternal toxicity. Breastfeeding: Unknown. Ephedrine is present in human milk in a single case report; effects on infant and milk production unknown. Weigh breastfeeding benefits against maternal need.
What does Ephedrine interact with?
MediHelp lists 170 known interactions for Ephedrine. Contraindicated: 6 · Major: 6 · Moderate: 88 · Minor: 70. The most serious include Isocarboxazid, Phenelzine, Procarbazine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
