医薬品リファレンス
Givinostat
Givinostat is a medicine in the class miscellaneous. It is used for duchenne muscular dystrophy.
- 薬効分類: Miscellaneous
- 効能・効果: Duchenne Muscular Dystrophy
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Miscellaneous
- ATCコード
- M09AX14
- 一般的な剤形
- 経口懸濁液
- 一般的な規格
- 8.86 mg/ml
- 既知の相互作用
- 104 (重大: 45 · 中等度: 36 · 軽度: 23)
- 商品名
- 1
- 国・市場
- 2
何に使われるか
作用のしくみ
Givinostat is a histone deacetylase inhibitor. The precise mechanism by which it acts in DMD is unknown.
妊娠と授乳
- 妊娠
- Unsafe Used for Duchenne muscular dystrophy, which affects almost only boys, so there are no pregnancy data. In rats and rabbits it lowered fetal weight and raised fetal and pup deaths and behaviour changes, some below human exposure.
- 授乳
- Unknown No human or animal data on milk. LactMed: highly protein-bound, so milk levels are likely very low; not a reason to stop breastfeeding, but use with caution and watch the infant for diarrhoea, vomiting, bruising or bleeding.
報告されている副作用
- Diarrhea
- Abdominal pain
- Thrombocytopenia
- Nausea/vomiting
- Hypertriglyceridemia
- Pyrexia
注意が必要な方
- Dose-related thrombocytopenia and myelosuppression (anemia, neutropenia); monitor blood counts every 2 weeks for first 2 months, at month 3, then every 3 months.
- Increased triglycerides; monitor at 1 month, 3 months, 6 months, then every 6 months. Discontinue if they remain elevated despite diet and dose adjustment.
- Gastrointestinal disturbances (diarrhea, nausea/vomiting, abdominal pain); consider antiemetics or antidiarrheals and replace fluids and electrolytes.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (104)
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
- Chlorpromazine + Givinostat Major
- Citalopram + Givinostat Major
- Clomipramine + Givinostat Major
- Clozapine + Givinostat Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Givinostatの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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よくある質問
What is Givinostat used for?
Givinostat is a medicine in the class miscellaneous. It is used for Duchenne Muscular Dystrophy.
What side effects have been reported with Givinostat?
Diarrhea, Abdominal pain, Thrombocytopenia, Nausea/vomiting, Hypertriglyceridemia, Pyrexia.
Can Givinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Used for Duchenne muscular dystrophy, which affects almost only boys, so there are no pregnancy data. In rats and rabbits it lowered fetal weight and raised fetal and pup deaths and behaviour changes, some below human exposure. Breastfeeding: Unknown. No human or animal data on milk. LactMed: highly protein-bound, so milk levels are likely very low; not a reason to stop breastfeeding, but use with caution and watch the infant for diarrhoea, vomiting, bruising or bleeding.
What does Givinostat interact with?
MediHelp lists 104 known interactions for Givinostat. Major: 45 · Moderate: 36 · Minor: 23. The most serious include Abiraterone, Amiodarone, Amisulpride.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
