相互作用
Amiodarone + Givinostat
重症度: 重大
Amiodarone and Givinostat: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Givinostat can prolong the QT interval and amiodarone adds to this effect, increasing torsades de pointes risk.
この相互作用をわかりやすく説明すると
Amiodarone and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Givinostat belongs to Miscellaneous.
なぜ起こるのか
Additive QT interval prolongation.
対処法
Avoid if possible; otherwise obtain ECGs at start and during treatment, and withhold givinostat if QTc exceeds 500 ms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとGivinostatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Givinostatのその他の相互作用
よくある質問
Can I take Amiodarone with Givinostat?
MediHelp rates the interaction as major. Amiodarone and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval and amiodarone adds to this effect, increasing torsades de pointes risk.
How serious is the interaction between Amiodarone and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECGs at start and during treatment, and withhold givinostat if QTc exceeds 500 ms.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
