相互作用
Abiraterone + Givinostat
重症度: 重大
Abiraterone and Givinostat: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is higher with electrolyte disturbances or underlying heart disease.
この相互作用をわかりやすく説明すると
Abiraterone and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abiraterone belongs to Endocrine; Givinostat belongs to Miscellaneous.
なぜ起こるのか
Additive QTc prolongation.
対処法
Obtain a baseline ECG and repeat during therapy, and correct potassium and magnesium. Withhold givinostat if QTc becomes markedly prolonged.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbirateroneとGivinostatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Abirateroneのその他の相互作用
Givinostatのその他の相互作用
よくある質問
Can I take Abiraterone with Givinostat?
MediHelp rates the interaction as major. Abiraterone and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is higher with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Abiraterone and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat during therapy, and correct potassium and magnesium. Withhold givinostat if QTc becomes markedly prolonged.
What other medicines interact with Abiraterone?
MediHelp also lists interactions of Abiraterone with, for example, Radium-223 dichloride, Thioridazine, Amobarbital. The full list is on the Abiraterone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
