Drug reference
megestrol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Neoplastics)
Mechanism of action
Progestin derivative with antiestrogenic properties; interferes with estrogen cycle, resulting in lower luteinizing hormone (LH) titer; antineoplastic properties may come from direct effect on endometrium through anti-LH effect mediated via pituitary
Common side effects
- Rash
- Insomnia
- Amenorrhea
- Hypertension
- Thrombophlebitis
- Mood swings
- Deep vein thrombosis
Contraindications
- Known or suspected pregnancy Acute thrombophlebitis, thromboembolic disorder, breast cancer Undiagnosed abnormal genital bleeding Prophylaxis of weight loss Documented hypersensitivity May induce vaginal bleeding in women
Related conditions
Frequently asked questions
What drug class is megestrol?
megestrol belongs to: Oncology.
How does megestrol work?
Progestin derivative with antiestrogenic properties; interferes with estrogen cycle, resulting in lower luteinizing hormone (LH) titer; antineoplastic properties may come from direct effect on endometrium through anti-LH effect mediated via pituitary
What are the common side effects of megestrol?
Rash, Insomnia, Amenorrhea, Hypertension, Thrombophlebitis, Mood swings, Deep vein thrombosis
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