医薬品リファレンス
Oritavancin
Oritavancin is a medicine in the class anti bacterial. It is used for skin infections.
- 薬効分類: Anti Bacterial
- 効能・効果: skin infections
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Bacterial
- ATCコード
- J01XA05
- 一般的な剤形
- 注射剤
- 一般的な規格
- 400 mg, 1200 mg/40 ml
- 既知の相互作用
- 12 (併用禁忌: 1 · 中等度: 1 · 軽度: 10)
- 商品名
- 3
- 国・市場
- 2
何に使われるか
作用のしくみ
Oritavancin is a lipoglycopeptide antibacterial drug; the label gives no further mechanism detail.
成人の通常用量（添付文書の要約）
ABSSSI (adults 18 years and older): 1,200 mg as a single dose by intravenous infusion over 1 hour.
妊娠と授乳
- 妊娠
- Unknown No human data; no effects on embryo-fetal development or survival in rats or rabbits at doses about 25% of the single clinical dose. Weigh the need for this single-dose antibiotic against the unknown risk.
- 授乳
- Unknown No human milk data; it passes into rat milk. LactMed: poorly absorbed by mouth, so unlikely to reach the infant's blood; watch for diarrhoea or thrush. With no published experience, an alternative may be preferred, especially with a newborn or preterm infant.
報告されている副作用
- Headache
- Nausea
- Vomiting
- Limb and subcutaneous abscesses
- Diarrhea
禁忌
- Intravenous unfractionated heparin is contraindicated for 120 hours (5 days) after administration because aPTT may remain falsely elevated.
- Known hypersensitivity to oritavancin products.
注意が必要な方
- Coagulation test interference: aPTT prolonged up to 120 hours, PT/INR up to 12 hours, ACT up to 24 hours; consider a chromogenic Factor Xa assay or an alternative anticoagulant not requiring aPTT.
- Serious hypersensitivity including anaphylaxis; discontinue infusion if it occurs and monitor patients with glycopeptide allergy.
- Infusion related reactions; stopping or slowing the infusion may stop them.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (12)
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Cyclosporin + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Flecainide + Oritavancin Minor
- Oritavancin + Phenytoin Minor
- Oritavancin + Quinidine Minor
- Oritavancin + Quinine Minor
- Oritavancin + Sirolimus Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Oritavancinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
WebでPro+を7日間無料でお試し。カード登録不要。
よくある質問
What is Oritavancin used for?
Oritavancin is a medicine in the class anti bacterial. It is used for Skin infections.
What side effects have been reported with Oritavancin?
Headache, Nausea, Vomiting, Limb and subcutaneous abscesses, Diarrhea.
Can Oritavancin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data; no effects on embryo-fetal development or survival in rats or rabbits at doses about 25% of the single clinical dose. Weigh the need for this single-dose antibiotic against the unknown risk. Breastfeeding: Unknown. No human milk data; it passes into rat milk. LactMed: poorly absorbed by mouth, so unlikely to reach the infant's blood; watch for diarrhoea or thrush. With no published experience, an alternative may be preferred, especially with a newborn or preterm infant.
What does Oritavancin interact with?
MediHelp lists 12 known interactions for Oritavancin. Contraindicated: 1 · Moderate: 1 · Minor: 10. The most serious include Heparin, Warfarin, Carbamazepine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
