医薬品リファレンス
Orlistat
Orlistat is a medicine in the class miscellaneous. It is used for obesity.
- 薬効分類: Miscellaneous
- 効能・効果: obesity
最終更新日
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要点
- 薬効分類
- Miscellaneous
- ATCコード
- A08AB01
- 一般的な剤形
- カプセル剤
- 一般的な規格
- 120 mg, 60 mg
- 既知の相互作用
- 70 (重大: 3 · 中等度: 44 · 軽度: 23)
- 商品名
- 25
- 国・市場
- 5
何に使われるか
作用のしくみ
Inhibits gastric and pancreatic lipases, prevents triglyceride hydrolysis resulting in decreased absorption of dietary fats
成人の通常用量（添付文書の要約）
(Xenical): 120 mg PO q8hr with each fat-containing meal (during or up to 1 hr after the meal), doses >120 mg TID show no additional benefit
妊娠と授乳
- 妊娠
- Unknown Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution.
- 授乳
- Safe Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
報告されている副作用
- Flatulence
- Oily spotting
- Fatty/oily stool
- Increased defecation
注意が必要な方
- Daily fat intake (30% of calories), carbohydrate, and protein should be evenly distributed over 3 main meals
- Postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure with some cases resulting in liver transplant or death
- Some patients may develop increased levels of urinary oxalate following treatment; cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure reported
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (70)
- Cyclosporin + Orlistat Major
- Cyclosporine + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
- Clobazam + Orlistat Moderate
- Clonazepam + Orlistat Moderate
- Clorazepate + Orlistat Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Orlistatの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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よくある質問
What is Orlistat used for?
Orlistat is a medicine in the class miscellaneous. It is used for Obesity.
What side effects have been reported with Orlistat?
Flatulence, Oily spotting, Fatty/oily stool, Increased defecation.
Can Orlistat be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution. Breastfeeding: Safe. Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
What does Orlistat interact with?
MediHelp lists 70 known interactions for Orlistat. Major: 3 · Moderate: 44 · Minor: 23. The most serious include Cyclosporin, Cyclosporine, Triheptanoin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
