相互作用
Cyclosporine + Orlistat
重症度: 重大
Cyclosporine and Orlistat: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Orlistat can lower cyclosporine blood concentrations and has been associated with subtherapeutic levels in transplant recipients. This risks acute rejection if the drop goes unnoticed.
この相互作用をわかりやすく説明すると
Cyclosporine and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Orlistat reduces dietary fat absorption and may impair absorption of the highly lipophilic cyclosporine from the gut.
対処法
Avoid the combination where possible; if used, monitor cyclosporine trough levels closely and adjust the dose. Give cyclosporine at least 3 hours apart from orlistat.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporineとOrlistatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Orlistatのその他の相互作用
よくある質問
Can I take Cyclosporine with Orlistat?
MediHelp rates the interaction as major. Cyclosporine and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orlistat can lower cyclosporine blood concentrations and has been associated with subtherapeutic levels in transplant recipients. This risks acute rejection if the drop goes unnoticed.
How serious is the interaction between Cyclosporine and Orlistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor cyclosporine trough levels closely and adjust the dose. Give cyclosporine at least 3 hours apart from orlistat.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporin, Triheptanoin, Amiodarone. The full list is on the Orlistat page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
