医薬品リファレンス
Palovarotene
Palovarotene is a medicine in the class miscellaneous. It is used for heterotopic ossification.
- 薬効分類: Miscellaneous
- 効能・効果: heterotopic ossification
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- 一般的な剤形
- カプセル剤
- 既知の相互作用
- 47 (併用禁忌: 2 · 重大: 34 · 中等度: 7 · 軽度: 4)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Retinoic acid receptor agonist with selectivity for the gamma subtype (RARγ). Binding to RARγ decreases BMP/ALK2 downstream signaling by inhibiting SMAD1/5/8 phosphorylation, which reduces endochondral bone formation.
成人の通常用量（添付文書の要約）
FOP, adults and patients 14 years and older, daily dose: 5 mg orally once daily with food. Stop daily dosing when flare-up dosing begins.
妊娠と授乳
- 妊娠
- Unsafe Contraindicated in pregnancy; can cause fetal harm. Retinoid-type malformations were seen in rats. No human data are available.
- 授乳
- Unsafe No data on presence in milk. Breastfeeding is not recommended during treatment and for at least 1 month after the final dose.
報告されている副作用
- Dry skin
- Dry lips
- Arthralgia
- Pruritus
- Pain in extremity
- Rash
警告（枠囲み警告）
- Embryo-fetal toxicity: contraindicated in pregnancy and may cause fetal harm. Give only if conditions for pregnancy prevention are met.
禁忌
- Pregnancy.
- History of allergy or hypersensitivity to retinoids or any component of SOHONOS.
注意が必要な方
- Embryo-fetal toxicity: verify non-pregnancy before, during and 1 month after treatment; use effective contraception; do not donate blood during therapy and for 1 week after.
- Irreversible premature epiphyseal closure in growing children; assess baseline skeletal maturity and monitor every 6 to 12 months.
- Mucocutaneous reactions occurred in 98% of patients and may increase the risk of skin and soft tissue infections; photosensitivity may occur.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (47)
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
- Carbamazepine + Palovarotene Major
- Chloramphenicol + Palovarotene Major
- Clarithromycin + Palovarotene Major
- Crizotinib + Palovarotene Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Palovaroteneの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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よくある質問
What is Palovarotene used for?
Palovarotene is a medicine in the class miscellaneous. It is used for Heterotopic ossification.
What side effects have been reported with Palovarotene?
Dry skin, Dry lips, Arthralgia, Pruritus, Pain in extremity, Rash. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy and may cause fetal harm.
Can Palovarotene be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; can cause fetal harm. Retinoid-type malformations were seen in rats. No human data are available. Breastfeeding: Unsafe. No data on presence in milk. Breastfeeding is not recommended during treatment and for at least 1 month after the final dose.
What does Palovarotene interact with?
MediHelp lists 47 known interactions for Palovarotene. Contraindicated: 2 · Major: 34 · Moderate: 7 · Minor: 4. The most serious include Acitretin, Isotretinoin, Amiodarone.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
