相互作用
Acitretin + Palovarotene
重症度: 併用禁忌
Acitretin and Palovarotene: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Both are retinoids, and using them together adds to total retinoid exposure. This increases the risk of hypervitaminosis A toxicity, including skin, bone, liver and lipid effects, and additive teratogenicity.
この相互作用をわかりやすく説明すると
Acitretin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Acitretin belongs to Miscellaneous; Palovarotene belongs to Miscellaneous.
なぜ起こるのか
Additive retinoid pharmacodynamic effects leading to hypervitaminosis A.
対処法
Do not combine; avoid other oral retinoids during palovarotene therapy. Choose a non-retinoid alternative.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcitretinとPalovaroteneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Acitretinのその他の相互作用
Palovaroteneのその他の相互作用
よくある質問
Can I take Acitretin with Palovarotene?
MediHelp rates the interaction as contraindicated. Acitretin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are retinoids, and using them together adds to total retinoid exposure. This increases the risk of hypervitaminosis A toxicity, including skin, bone, liver and lipid effects, and additive teratogenicity.
How serious is the interaction between Acitretin and Palovarotene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid other oral retinoids during palovarotene therapy. Choose a non-retinoid alternative.
What other medicines interact with Acitretin?
MediHelp also lists interactions of Acitretin with, for example, Demeclocycline, Doxycycline, Ethanol. The full list is on the Acitretin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
