相互作用
Crizotinib + Palovarotene
重症度: 重大
Crizotinib and Palovarotene: major interaction.
最終更新日
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概要
Crizotinib may increase palovarotene exposure, raising retinoid toxicity such as mucocutaneous effects and premature growth plate closure.
この相互作用をわかりやすく説明すると
Crizotinib and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Palovarotene belongs to Miscellaneous.
なぜ起こるのか
Crizotinib inhibits CYP3A4 metabolism of palovarotene.
対処法
Avoid combination; if unavoidable, reduce palovarotene by 50% and monitor for retinoid adverse effects.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CrizotinibとPalovaroteneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Crizotinibのその他の相互作用
Palovaroteneのその他の相互作用
よくある質問
Can I take Crizotinib with Palovarotene?
MediHelp rates the interaction as major. Crizotinib and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib may increase palovarotene exposure, raising retinoid toxicity such as mucocutaneous effects and premature growth plate closure.
How serious is the interaction between Crizotinib and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if unavoidable, reduce palovarotene by 50% and monitor for retinoid adverse effects.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
