医薬品リファレンス
Pentostatin
Pentostatin is a medicine in the class oncology. It is used for hairy cell leukemia.
- 薬効分類: Oncology
- 効能・効果: hairy cell leukemia
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 注射剤
- 一般的な規格
- 2 mg/ml
- 既知の相互作用
- 14 (併用禁忌: 3 · 重大: 6 · 中等度: 4 · 軽度: 1)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA). ADA inhibition leads to cytotoxicity, believed to be due to elevated intracellular dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase.
成人の通常用量（添付文書の要約）
Hairy cell leukemia: 4 mg/m2 intravenously every other week, by bolus injection or diluted and infused over 20 to 30 minutes; higher doses not recommended
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm; teratogenic in animals; no adequate human studies. Advise women to avoid pregnancy.
- 授乳
- Unsafe Not known if excreted in milk; advise not to breastfeed during therapy and for 1 week after the last dose.
報告されている副作用
- Nausea and/or vomiting
- Fever
- Rash
- Fatigue
- Leukopenia
- Pruritus
警告（枠囲み警告）
- Give under supervision of a physician experienced in cancer chemotherapy. Higher doses than recommended are not advised; doses of 20-50 mg/m2 in divided doses over 5 days caused severe renal, liver, pulmonary and CNS toxicities. With fludarabine phosphate, 4 of 6 patients had severe or fatal pulmonary toxicity; the combination is not recommended.
禁忌
- Hypersensitivity to pentostatin (NIPENT).
注意が必要な方
- Myelosuppression, mainly in the first few courses; monitor complete blood counts frequently early in treatment.
- Pre-existing infections have worsened, in some cases fatally; control infection before starting or resuming.
- Rashes, occasionally severe, are common and may worsen with continued treatment.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (14)
- Carmustine + Pentostatin Contraindicated
- Etoposide + Pentostatin Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Cyclophosphamide + Pentostatin Major
- Deferiprone + Pentostatin Major
- Fingolimod + Pentostatin Major
- Nelarabine + Pentostatin Major
- Pentostatin + Siponimod Major
- Pentostatin + Tofacitinib Major
- Allopurinol + Pentostatin Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Pentostatinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Pentostatin used for?
Pentostatin is a medicine in the class oncology. It is used for Hairy cell leukemia.
What side effects have been reported with Pentostatin?
Nausea and/or vomiting, Fever, Rash, Fatigue, Leukopenia, Pruritus. Serious warning: Give under supervision of a physician experienced in cancer chemotherapy.
Can Pentostatin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; teratogenic in animals; no adequate human studies. Advise women to avoid pregnancy. Breastfeeding: Unsafe. Not known if excreted in milk; advise not to breastfeed during therapy and for 1 week after the last dose.
What does Pentostatin interact with?
MediHelp lists 14 known interactions for Pentostatin. Contraindicated: 3 · Major: 6 · Moderate: 4 · Minor: 1. The most serious include Carmustine, Etoposide, Fludarabine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
