相互作用
Nelarabine + Pentostatin
重症度: 重大
Nelarabine and Pentostatin: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Pentostatin inhibits adenosine deaminase, which converts nelarabine to ara-G. Combination may alter nelarabine handling and has been associated with increased neurologic toxicity.
この相互作用をわかりやすく説明すると
Nelarabine and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nelarabine belongs to Oncology; Pentostatin belongs to Oncology.
なぜ起こるのか
Adenosine deaminase inhibition by pentostatin interferes with nelarabine metabolism and may increase neurotoxicity.
対処法
Avoid the combination and monitor closely for neurologic toxicity if unavoidable.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、NelarabineとPentostatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Nelarabineのその他の相互作用
Pentostatinのその他の相互作用
よくある質問
Can I take Nelarabine with Pentostatin?
MediHelp rates the interaction as major. Nelarabine and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin inhibits adenosine deaminase, which converts nelarabine to ara-G. Combination may alter nelarabine handling and has been associated with increased neurologic toxicity.
How serious is the interaction between Nelarabine and Pentostatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and monitor closely for neurologic toxicity if unavoidable.
What other medicines interact with Nelarabine?
MediHelp also lists interactions of Nelarabine with, for example, Deferiprone, Siponimod, Tofacitinib. The full list is on the Nelarabine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
