相互作用
Etoposide + Pentostatin
重症度: 併用禁忌
Etoposide and Pentostatin: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.
この相互作用をわかりやすく説明すると
Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Etoposide belongs to Oncology; Pentostatin belongs to Oncology.
なぜ起こるのか
Mechanism not established; additive pulmonary and cardiovascular toxicity is suspected.
対処法
Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EtoposideとPentostatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pentostatinのその他の相互作用
Etoposideのその他の相互作用
よくある質問
Can I take Etoposide with Pentostatin?
MediHelp rates the interaction as contraindicated. Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.
How serious is the interaction between Etoposide and Pentostatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Fludarabine, Cyclophosphamide. The full list is on the Pentostatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
