医薬品リファレンス
Secnidazole
Secnidazole is a medicine in the class anti parasitic. It is used for bacterial vaginosis.
- 薬効分類: Anti Parasitic
- 効能・効果: bacterial vaginosis
最終更新日
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要点
- 薬効分類
- Anti Parasitic
- 一般的な剤形
- 錠剤, 分包
- 一般的な規格
- 500 mg, 1 g, 2 g/4.8 g
- 既知の相互作用
- 1 (中等度: 1)
- 商品名
- 13
- 国・市場
- 4
何に使われるか
作用のしくみ
Secnidazole is a nitroimidazole derivative; 5-nitroimidazoles enters the bacterial cell as an inactive prodrug where the nitro group is reduced by bacterial enzymes to radical anions. It is believed that these radical anions interfere with bacterial DNA synthesis of susceptible isolates
成人の通常用量（添付文書の要約）
Bacterial Vaginosis: 1 packet (2 grams) of granules or tablet PO once as a single dose, without regard to timing of meals
妊娠と授乳
- 妊娠
- Unknown Limited human data; no harm in rats or rabbits at up to 4 times the clinical dose. A nitroimidazole like metronidazole, which has far more pregnancy data and is preferred for bacterial vaginosis or trichomonas in pregnancy.
- 授乳
- Unknown No human milk data; related drugs pass into milk. US label: breastfeeding not recommended during treatment and for 96 hours after the single dose (possible tumour risk in animals); pump and discard. LactMed: vaginal treatments give lower milk levels. e-lactancia: compatible.
報告されている副作用
- Headache
- Vomiting
- Diarrhea
- Nausea
- Vulvovaginal candidiasis
- Dysgeusia
禁忌
- Hypersensitivity to secnidazole, excipients of the formulation, or other nitroimidazole derivatives
- Patients with Cockayne syndrome
注意が必要な方
- Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes reported after initiation of metronidazole in patients with Cockayne syndrome
- Carcinogenicity has been seen in mice and rats treated long term with nitroimidazole derivatives, which are structurally related to secnidazole; avoid long-term use
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
- Ethanol + Secnidazole Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Secnidazoleの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Secnidazole used for?
Secnidazole is a medicine in the class anti parasitic. It is used for Bacterial vaginosis, Trichomoniasis.
What side effects have been reported with Secnidazole?
Headache, Vomiting, Diarrhea, Nausea, Vulvovaginal candidiasis, Dysgeusia.
Can Secnidazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data; no harm in rats or rabbits at up to 4 times the clinical dose. A nitroimidazole like metronidazole, which has far more pregnancy data and is preferred for bacterial vaginosis or trichomonas in pregnancy. Breastfeeding: Unknown. No human milk data; related drugs pass into milk. US label: breastfeeding not recommended during treatment and for 96 hours after the single dose (possible tumour risk in animals); pump and discard. LactMed: vaginal treatments give lower milk levels. e-lactancia: compatible.
What does Secnidazole interact with?
MediHelp lists 1 known interactions for Secnidazole. Moderate: 1. The most serious include Ethanol.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
