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Pentamidine

Pentamidine is a medicine in the class anti parasitic. It is used for pneumonia.

最終更新日 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Anti Parasitic
一般的な剤形
注射剤, 吸入器
一般的な規格
300 mg/3 ml, 300 mg/6 ml
既知の相互作用
156 (併用禁忌: 9 · 重大: 113 · 中等度: 33 · 軽度: 1)
商品名
2
国・市場
1

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Aromatic diamidine; mode of action not fully understood. In vitro it interferes with protozoal nuclear metabolism by inhibiting DNA, RNA, phospholipid and protein synthesis.

成人の通常用量（添付文書の要約）

Pneumocystis carinii pneumonia: 4 mg/kg once a day, IM or IV, for 14 to 21 days; therapy longer than 21 days may be associated with increased toxicity

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unknown Very limited human data; a miscarriage was reported after 1st-trimester inhaled use (UK label). IV pentamidine was embryolethal in rats, without birth defects. US label: only if clearly needed; UK label: only if the mother's condition requires it. Treating serious infections such as PCP comes first.
授乳
Unknown Not known if it passes into milk; no LactMed record. UK label: stop breastfeeding during treatment; US label: decide on nursing or the drug. Inhaled use gives low blood levels, so infant exposure is likely lower, but there are no data.

報告されている副作用

  • Elevated serum creatinine
  • Impaired renal function
  • Sterile abscess, necrosis, pain or induration at IM site
  • Leukopenia
  • Elevated liver function tests
  • Azotemia

禁忌

  • History of hypersensitivity to pentamidine isethionate.

注意が必要な方

  • Fatalities from severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported with IM and IV use; limit use to patients with demonstrated Pneumocystis carinii.
  • Sudden severe hypotension can occur after a single dose; patients should lie down with close blood pressure monitoring and resuscitation equipment available.
  • Extravasation may cause ulceration, tissue necrosis or sloughing; discontinue the infusion and restart in another vein.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (156)

All 156 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Pentamidineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • IV preparation and dilution
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同じ分類のほかの薬剤

よくある質問

What is Pentamidine used for?

Pentamidine is a medicine in the class anti parasitic. It is used for Pneumonia.

What side effects have been reported with Pentamidine?

Elevated serum creatinine, Impaired renal function, Sterile abscess, necrosis, pain or induration at IM site, Leukopenia, Elevated liver function tests, Azotemia.

Can Pentamidine be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. Very limited human data; a miscarriage was reported after 1st-trimester inhaled use (UK label). IV pentamidine was embryolethal in rats, without birth defects. US label: only if clearly needed; UK label: only if the mother's condition requires it. Treating serious infections such as PCP comes first. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. UK label: stop breastfeeding during treatment; US label: decide on nursing or the drug. Inhaled use gives low blood levels, so infant exposure is likely lower, but there are no data.

What does Pentamidine interact with?

MediHelp lists 156 known interactions for Pentamidine. Contraindicated: 9 · Major: 113 · Moderate: 33 · Minor: 1. The most serious include Clomipramine, Desipramine, Dronedarone.

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