医薬品リファレンス
Sodium oxybate
Sodium oxybate is a medicine in the class central nervous system. It is used for narcolepsy.
- 薬効分類: Central Nervous System
- 効能・効果: narcolepsy
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Central Nervous System
- ATCコード
- N07XX04
- 一般的な剤形
- 経口懸濁液, 溶液
- 一般的な規格
- 50%
- 既知の相互作用
- 99 (併用禁忌: 17 · 重大: 79 · 中等度: 3)
- 商品名
- 3
- 国・市場
- 2
何に使われるか
作用のしくみ
CNS depressant. Mechanism in narcolepsy is unknown. It is the sodium salt of GHB, a metabolite of GABA; therapeutic effects are hypothesized to be mediated through GABA B actions at noradrenergic, dopaminergic and thalamocortical neurons.
成人の通常用量（添付文書の要約）
Narcolepsy (cataplexy or EDS): start 4.5 g per night orally in two divided doses (2.25 g at bedtime and 2.25 g 2.5 to 4 hours later); increase by 1.5 g per night at weekly intervals; effective range 6 g to 9 g per night; doses higher than 9 g per night not studied.
妊娠と授乳
- 妊娠
- Unknown No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose.
- 授乳
- Unknown GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
報告されている副作用
- Nausea
- Dizziness
- Vomiting
- Somnolence
- Enuresis
- Tremor
警告（枠囲み警告）
- CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
禁忌
- Combination with sedative hypnotics.
- Combination with alcohol.
- Succinic semialdehyde dehydrogenase deficiency.
注意が必要な方
- Concurrent use with other CNS depressants may increase risk of respiratory depression, hypotension, profound sedation, syncope and death; consider dose reduction or discontinuation.
- No hazardous activities requiring mental alertness for at least 6 hours after dosing.
- May impair respiratory drive; increased central apneas and desaturation observed in adults and children.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (99)
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Eszopiclone + Sodium oxybate Contraindicated
- Methadone + Sodium oxybate Contraindicated
- Midazolam + Sodium oxybate Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Sodium oxybateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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よくある質問
What is Sodium oxybate used for?
Sodium oxybate is a medicine in the class central nervous system. It is used for Narcolepsy.
What side effects have been reported with Sodium oxybate?
Nausea, Dizziness, Vomiting, Somnolence, Enuresis, Tremor. Serious warning: CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
Can Sodium oxybate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose. Breastfeeding: Unknown. GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
What does Sodium oxybate interact with?
MediHelp lists 99 known interactions for Sodium oxybate. Contraindicated: 17 · Major: 79 · Moderate: 3. The most serious include Alprazolam, Amobarbital, Butorphanol.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
