相互作用
Clonazepam + Sodium oxybate
重症度: 併用禁忌
Clonazepam and Sodium oxybate: contraindicated interaction.
最終更新日
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概要
Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
この相互作用をわかりやすく説明すると
Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clonazepam belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
なぜ起こるのか
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
対処法
Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、ClonazepamとSodium oxybateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clonazepamのその他の相互作用
Sodium oxybateのその他の相互作用
よくある質問
Can I take Clonazepam with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
How serious is the interaction between Clonazepam and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
