相互作用
Clorazepate + Sodium oxybate
重症度: 併用禁忌
Clorazepate and Sodium oxybate: contraindicated interaction.
最終更新日
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概要
Sodium oxybate is a potent CNS depressant, and with a benzodiazepine it can cause profound sedation, respiratory depression, coma and death. Labeling restricts concomitant use with sedatives.
この相互作用をわかりやすく説明すると
Clorazepate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clorazepate belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
なぜ起こるのか
Additive CNS and respiratory depression via GABA-B and GABA-A mediated effects.
対処法
Avoid the combination and choose an alternative to the benzodiazepine where possible. If unavoidable, monitor closely for respiratory depression.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、ClorazepateとSodium oxybateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clorazepateのその他の相互作用
Sodium oxybateのその他の相互作用
よくある質問
Can I take Clorazepate with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Clorazepate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a potent CNS depressant, and with a benzodiazepine it can cause profound sedation, respiratory depression, coma and death. Labeling restricts concomitant use with sedatives.
How serious is the interaction between Clorazepate and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine where possible. If unavoidable, monitor closely for respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clorazepate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
