相互作用
Abacavir + Ribavirin
重症度: 中等度
Abacavir and Ribavirin: moderate interaction.
最終更新日
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概要
Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.
この相互作用をわかりやすく説明すると
Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Abacavir belongs to Anti Virals; Ribavirin belongs to Anti Virals.
なぜ起こるのか
Possible additive mitochondrial toxicity; ribavirin may also alter intracellular nucleoside phosphorylation, though this is not firmly established for abacavir.
対処法
Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbacavirとRibavirinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ribavirinのその他の相互作用
Abacavirのその他の相互作用
よくある質問
Can I take Abacavir with Ribavirin?
MediHelp rates the interaction as moderate. Abacavir and Ribavirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribavirin and nucleoside analogues such as abacavir can both disturb mitochondrial function. The combination may raise the risk of lactic acidosis and hepatic decompensation, particularly in patients with HIV/HCV coinfection and advanced liver disease.
How serious is the interaction between Abacavir and Ribavirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lactate, liver function and clinical signs of lactic acidosis, especially in cirrhosis. Stop the offending agents if symptomatic hyperlactatemia or hepatic decompensation develops.
What other medicines interact with Ribavirin?
MediHelp also lists interactions of Ribavirin with, for example, Didanosine, Stavudine, Zidovudine. The full list is on the Ribavirin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
