相互作用
Lamivudine + Ribavirin
重症度: 軽度
Lamivudine and Ribavirin: minor interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Ribavirin and lamivudine have no established pharmacokinetic interaction, and the concern is largely theoretical additive mitochondrial toxicity and lactic acidosis. Clinical data in HIV and hepatitis C coinfection have not shown a significant problem.
この相互作用をわかりやすく説明すると
Lamivudine and Ribavirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamivudine belongs to Anti Virals; Ribavirin belongs to Anti Virals.
なぜ起こるのか
Theoretical additive mitochondrial toxicity; no established pharmacokinetic interaction.
対処法
No dose change is needed; monitor for symptoms of lactic acidosis, and monitor hemoglobin and liver function during ribavirin therapy.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LamivudineとRibavirinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ribavirinのその他の相互作用
Lamivudineのその他の相互作用
よくある質問
Can I take Lamivudine with Ribavirin?
MediHelp rates the interaction as minor. Lamivudine and Ribavirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribavirin and lamivudine have no established pharmacokinetic interaction, and the concern is largely theoretical additive mitochondrial toxicity and lactic acidosis. Clinical data in HIV and hepatitis C coinfection have not shown a significant problem.
How serious is the interaction between Lamivudine and Ribavirin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for symptoms of lactic acidosis, and monitor hemoglobin and liver function during ribavirin therapy.
What other medicines interact with Ribavirin?
MediHelp also lists interactions of Ribavirin with, for example, Didanosine, Stavudine, Zidovudine. The full list is on the Ribavirin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
