相互作用
Ribavirin + Zidovudine
重症度: 重大
Ribavirin and Zidovudine: major interaction.
最終更新日
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概要
Ribavirin may reduce the intracellular phosphorylation of zidovudine to its active form, potentially lowering antiretroviral activity. Both drugs also cause hematologic toxicity, so anemia and neutropenia may be worsened.
この相互作用をわかりやすく説明すると
Ribavirin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribavirin belongs to Anti Virals; Zidovudine belongs to Anti Virals.
なぜ起こるのか
Competition for intracellular phosphorylation reduces zidovudine activation, with additive bone marrow suppression.
対処法
Avoid zidovudine in patients receiving ribavirin and use another nucleoside backbone; if unavoidable, monitor HIV viral load and complete blood counts closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RibavirinとZidovudineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ribavirinのその他の相互作用
Zidovudineのその他の相互作用
よくある質問
Can I take Ribavirin with Zidovudine?
MediHelp rates the interaction as major. Ribavirin and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribavirin may reduce the intracellular phosphorylation of zidovudine to its active form, potentially lowering antiretroviral activity. Both drugs also cause hematologic toxicity, so anemia and neutropenia may be worsened.
How serious is the interaction between Ribavirin and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid zidovudine in patients receiving ribavirin and use another nucleoside backbone; if unavoidable, monitor HIV viral load and complete blood counts closely.
What other medicines interact with Ribavirin?
MediHelp also lists interactions of Ribavirin with, for example, Didanosine, Stavudine, Abacavir. The full list is on the Ribavirin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
