相互作用
Abobotulinumtoxina + Streptomycin
重症度: 重大
Abobotulinumtoxina and Streptomycin: major interaction.
最終更新日
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概要
Aminoglycosides impair neuromuscular transmission and can amplify the effect of botulinum toxin. This may produce excessive or widespread muscle weakness, including swallowing and breathing difficulty.
この相互作用をわかりやすく説明すると
Abobotulinumtoxina and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive neuromuscular blockade, with aminoglycosides reducing presynaptic acetylcholine release.
対処法
Avoid the combination where possible, or monitor closely for generalized weakness, dysphagia and respiratory compromise. Consider a lower toxin dose and delay streptomycin if feasible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbobotulinumtoxinaとStreptomycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Streptomycinのその他の相互作用
よくある質問
Can I take Abobotulinumtoxina with Streptomycin?
MediHelp rates the interaction as major. Abobotulinumtoxina and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides impair neuromuscular transmission and can amplify the effect of botulinum toxin. This may produce excessive or widespread muscle weakness, including swallowing and breathing difficulty.
How serious is the interaction between Abobotulinumtoxina and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor closely for generalized weakness, dysphagia and respiratory compromise. Consider a lower toxin dose and delay streptomycin if feasible.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Adefovir, Amikacin, Amphotericin b deoxycholate. The full list is on the Streptomycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
