相互作用
Acalabrutinib + Esomeprazole
重症度: 重大
Acalabrutinib and Esomeprazole: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Esomeprazole can substantially lower absorption of acalabrutinib tablets or capsules, which may weaken its anticancer effect. Because PPI acid suppression lasts a long time, separating the doses does not reliably prevent this.
この相互作用をわかりやすく説明すると
Acalabrutinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Higher gastric pH reduces the pH-dependent solubility and absorption of acalabrutinib.
対処法
Avoid PPIs with acalabrutinib. If acid suppression is needed, use an antacid taken 2 hours apart or an H2 blocker with acalabrutinib taken 2 hours before it, or switch to the tablet form, which is less affected.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcalabrutinibとEsomeprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Esomeprazoleのその他の相互作用
Acalabrutinibのその他の相互作用
よくある質問
Can I take Acalabrutinib with Esomeprazole?
MediHelp rates the interaction as major. Acalabrutinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esomeprazole can substantially lower absorption of acalabrutinib tablets or capsules, which may weaken its anticancer effect. Because PPI acid suppression lasts a long time, separating the doses does not reliably prevent this.
How serious is the interaction between Acalabrutinib and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with acalabrutinib. If acid suppression is needed, use an antacid taken 2 hours apart or an H2 blocker with acalabrutinib taken 2 hours before it, or switch to the tablet form, which is less affected.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Esomeprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
