相互作用
Atazanavir + Esomeprazole
重症度: 重大
Atazanavir and Esomeprazole: major interaction.
最終更新日
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概要
Atazanavir needs an acidic stomach to dissolve, so esomeprazole can markedly reduce its levels. This may lead to virologic failure and development of resistance.
この相互作用をわかりやすく説明すると
Atazanavir and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Esomeprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Higher gastric pH decreases atazanavir solubility and absorption.
対処法
Avoid PPIs in treatment-experienced patients. In treatment-naive patients on ritonavir-boosted atazanavir, keep the PPI dose to an omeprazole 20 mg equivalent, give it about 12 hours before atazanavir, and monitor viral load.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとEsomeprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Esomeprazoleのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Esomeprazole?
MediHelp rates the interaction as major. Atazanavir and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic stomach to dissolve, so esomeprazole can markedly reduce its levels. This may lead to virologic failure and development of resistance.
How serious is the interaction between Atazanavir and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients. In treatment-naive patients on ritonavir-boosted atazanavir, keep the PPI dose to an omeprazole 20 mg equivalent, give it about 12 hours before atazanavir, and monitor viral load.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
