相互作用
Aceclofenac + Probenecid
重症度: 中等度
Aceclofenac and Probenecid: moderate interaction.
最終更新日
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概要
Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.
この相互作用をわかりやすく説明すると
Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
なぜ起こるのか
Probenecid inhibits OAT-mediated renal tubular secretion of aceclofenac and its metabolites.
対処法
Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AceclofenacとProbenecidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Probenecidのその他の相互作用
Aceclofenacのその他の相互作用
よくある質問
Can I take Aceclofenac with Probenecid?
MediHelp rates the interaction as moderate. Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Aceclofenac and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
