相互作用
Aceclofenac + Sulphasalazine
重症度: 中等度
Aceclofenac and Sulphasalazine: moderate interaction.
最終更新日
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概要
Aceclofenac is an NSAID and sulfasalazine contains a salicylate-related moiety, so combined use may add to gastrointestinal irritation, renal effects and bleeding tendency. Clinically significant harm is uncommon but possible in at-risk patients.
この相互作用をわかりやすく説明すると
Aceclofenac and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Sulphasalazine belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive NSAID effects on platelet function, gastric mucosa and renal prostaglandins.
対処法
Use the lowest effective NSAID dose and monitor for gastrointestinal bleeding, renal function and blood counts. Consider gastroprotection in high-risk patients.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AceclofenacとSulphasalazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sulphasalazineのその他の相互作用
Aceclofenacのその他の相互作用
よくある質問
Can I take Aceclofenac with Sulphasalazine?
MediHelp rates the interaction as moderate. Aceclofenac and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aceclofenac is an NSAID and sulfasalazine contains a salicylate-related moiety, so combined use may add to gastrointestinal irritation, renal effects and bleeding tendency. Clinically significant harm is uncommon but possible in at-risk patients.
How serious is the interaction between Aceclofenac and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose and monitor for gastrointestinal bleeding, renal function and blood counts. Consider gastroprotection in high-risk patients.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
