医薬品リファレンス
Sulphasalazine
Sulphasalazine is a medicine in the class gastrointestinal tract. It is used for juvenile rheumatoid arthritis.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: juvenile rheumatoid arthritis
最終更新日
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要点
- 薬効分類
- Gastrointestinal Tract
- 別名
- Sulfasalazine
- 一般的な剤形
- 錠剤
- 一般的な規格
- 500 mg
- 既知の相互作用
- 100 (重大: 3 · 中等度: 50 · 軽度: 47)
- 商品名
- 6
- 国・市場
- 3
何に使われるか
作用のしくみ
Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase.
成人の通常用量（添付文書の要約）
Ulcerative Colitis: 3-4 g/day PO divided TID after meals; may start 1-2 g Day; >4g/day can increase risk of toxicity
妊娠と授乳
- 妊娠
- Safe UK label: use only if clearly needed (folate antagonism; neural tube defect reports, link unproven). Wide use for bowel disease and arthritis shows no rise in birth defects; BSR 2022: compatible throughout pregnancy. Take folic acid 5 mg daily from before conception through the first trimester.
- 授乳
- Safe Low levels pass into milk, but the sulfapyridine metabolite reaches the infant. UK label: avoid breastfeeding; US: caution, bloody diarrhoea reported. LactMed: guidelines call it acceptable for healthy term infants; watch for diarrhoea. Avoid with a jaundiced, preterm or G6PD-deficient newborn.
報告されている副作用
- Headache
- Anorexia
- Nausea, Vomiting
- Gastric distress
- Apparently reversible oligospermia
禁忌
- Hypersensitivity to sulfasalazine or its metabolites, to sulfonamides, or to salicylates
- Intestinal or urinary tract obstruction
- Porphyria
注意が必要な方
- Serious skin reactions, some of them fatal, including exfoliative dermatitis.
- Administer tablets with caution to patients with severe allergy or bronchial asthma; adequate fluid intake must be maintained in order to prevent crystalluria and stones.
- Oligospermia and infertility reported; however, withdrawal of drug appears to reverse these effects.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (100)
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
- Axicabtagene ciloleucel + Sulphasalazine Moderate
- Brexucabtagene autoleucel + Sulphasalazine Moderate
- Chlorpropamide + Sulphasalazine Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Sulphasalazineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Sulphasalazine used for?
Sulphasalazine is a medicine in the class gastrointestinal tract. It is used for Juvenile rheumatoid arthritis, Rheumatoid arthritis, Ulcerative colitis.
What side effects have been reported with Sulphasalazine?
Headache, Anorexia, Nausea, Vomiting, Gastric distress, Apparently reversible oligospermia.
Can Sulphasalazine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. UK label: use only if clearly needed (folate antagonism; neural tube defect reports, link unproven). Wide use for bowel disease and arthritis shows no rise in birth defects; BSR 2022: compatible throughout pregnancy. Take folic acid 5 mg daily from before conception through the first trimester. Breastfeeding: Safe. Low levels pass into milk, but the sulfapyridine metabolite reaches the infant. UK label: avoid breastfeeding; US: caution, bloody diarrhoea reported. LactMed: guidelines call it acceptable for healthy term infants; watch for diarrhoea. Avoid with a jaundiced, preterm or G6PD-deficient newborn.
What does Sulphasalazine interact with?
MediHelp lists 100 known interactions for Sulphasalazine. Major: 3 · Moderate: 50 · Minor: 47. The most serious include Deferiprone, Pexidartinib, Sepiapterin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
