相互作用
Acetylsalicylic acid + Lesinurad
重症度: 中等度
Acetylsalicylic acid and Lesinurad: moderate interaction.
最終更新日
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概要
High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
この相互作用をわかりやすく説明すると
Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
なぜ起こるのか
Salicylates interfere with renal urate handling at the tubular level, and this may counteract the uricosuric effect, though the exact mechanism is not firmly established.
対処法
Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Acetylsalicylic acidとLesinuradの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Acetylsalicylic acidのその他の相互作用
Lesinuradのその他の相互作用
よくある質問
Can I take Acetylsalicylic acid with Lesinurad?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
How serious is the interaction between Acetylsalicylic acid and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
